Tissue architecture delineates field cancerization in BRAFV600E-induced tumor development
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Differential gene expression in tumor adjacent histologically normal prostatic tissue indicates field cancerization.
Field cancerization denotes the occurrence of aberrant cells in tumor adjacent histologically normal tissues (TAHN). To characterize field cancerization in prostate cancer, we used RNA from paired patient tumor and TAHN tissues excised at 1 cm from the tumor margin and subjected them to microarray expression analysis comparative to RNA from normal cancer-free prostatic tissues. Eleven novel tra...
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Telomerase stabilizes chromosomes by maintaining telomere length, immortalizes mammalian cells, and is expressed in more than 90% of human tumors. However, the expression of human telomerase reverse transcriptase (hTERT) is not restricted to tumor cells. We have previously shown that a subpopulation of human mammary epithelial cells (HMEC) in tumor-adjacent, histologically normal (TAHN) breast ...
متن کاملBreast Field Cancerization: Isolation and Comparison of Telomerase-Expressing Cells in Tumor and Tumor-Adjacent, Histologically-Normal Breast Tissue Running Title: Telomerase expression in tumor-adjacent breast tissue
Telomerase stabilizes chromosomes by maintaining telomere length, immortalizes mammalian cells and is expressed in >90% of human tumors. However, the expression of human telomerase reverse transcriptase (hTERT) is not restricted to tumors cells. We have previously demonstrated that a subpopulation of human mammary epithelial cells (HMECs) in tumor-adjacent histologically-normal (TAHN) breast ti...
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Patients with a head and neck squamous cell carcinoma (HNSCC) often develop multiple (pre)malignant lesions. This finding led to the field cancerization theory, which hypothesizes that the entire epithelial surface of the upper aerodigestive tract has an increased risk for the development of (pre)malignant lesions because of multiple genetic abnormalities in the whole tissue region. Demonstrati...
متن کاملOral Field Cancerization: A Review
The concept of oral field cancerization (OFC) has been ever changing since its first description by Slaughter et al in 1953. The concept of OFC explains the mechanisms by which second primary tumors (SPTs) develop. SPTs are the tumors, which develop in the oral cavity in succession to the primary malignant tumors, which might vary in duration ranging from few months to years. The “classical” me...
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ژورنال
عنوان ژورنال: Disease Models & Mechanisms
سال: 2021
ISSN: 1754-8403,1754-8411
DOI: 10.1242/dmm.048887